Liver Carcinogenesis The Molecular Pathways

Contents Molecular pathways in hepatocyte proliferation 1 G.G.Skouteris HGF and liver growth regulation 13 G.KMichalopoulos Structure, pleiotropic actions and organotrophic roles 33 of hepatocyte growth factor K.Matsumoto and Τ.Nakamura Hepatocyte Growth Factor and its variant with a deletion 55 of five amino-acids are distinguishable in biological, physicochemical and immunochemical properties Ν Shi ma and K.Higashio Growth stimulation mediated by G protein-coupled receptors in hepatocytes: 71 Synergism with epidermal growth factor and mechanisms of signal transduction Protein tyrosine phosphatases in signal transduction 93 S-HShen and DBanville C-myc is essential for initiation of DNA synthesis 109 in EGF-stimulated hepatocyte cultures χ Stem cell activation in the acetylaminofluorene-treated regenerating 163 rat liver: A bile ductular reaction? Apoptosis and its role in hepatic carcinogenesis by non-genotoxic agents 181 Cell proliferation and cell death in the liver: 197 Patterns, mechanisms and measurements Preneoplastic changes during non-genotoxic hepatocarcinogenesis 215 CJ.Powell, B.Secretan and S.Cottrell mRNA composition of rat liver tumors initiated by aromatic amines 231 Liver γ-Glutamyl transpeptidase activity after cyclosporine A 249 and amlodipine treatment JGMaj, JJ.Tomaszewski and A .E.Haratym Enhanced expression of the 27KDa heat-shock protein 261 during DENA-induced hepatocarcinogenesis in rat and in human neoplastic and non-neoplastic liver tissues Hepatic recovery of dimethylnitrosamine-cirrhotic rats 275 after injection of the liver growth factor Cell contact-mediated regulation of hepatocyte differentiation/proliferation: 287 Role of LRP(s) χι Interactions of human hepatocytes with hepatitis Β virus. 301 Transcriptional involvement of the hepatitis Β virus protein in cellular 341 transduction systems. Protein-protein interactions with bZip transactivators OMAndrisani Role of duck hepatitis Β virus infection, aflatoxin Bj and p53 mutation 359 in hepatocellular carcinomas of ducks L.Cova The preparation and culturing of rat hepatocytes 373 PSkett Isolation and growth of hepatocytes and biliary epithelial cells 389 from normal and diseased human livers A novel strategy for isolating HEPR, 411 a human small intestinal cytidine deaminase Regenerating liver: Isolation of up-and down-regulated gene products 421 T. Hepatotrophic and renotrophic activities of HGF in vivo: 435 Possible application of HGF for hepatic and renal diseases KMatsumoto and Τ.Nakamura Targeted gene delivery and expression G.YWu 449 XII Studies on persistence and enhancement of targeted gene expression 457 GY.Wu The generation of tumor vaccines by adenovirus-enhanced transferrinfection 467 of cytokine genes into tumor cells